Blue Liner, Drama Guy and I recently tried Poop: The Game. The concept is admittedly gross but simple. Players lay down cards (poop) with numerical values. If you clog the toilet - meaning, your total discard score adds up to the number on the clog card - you take the discard pile. The object, like in UNO, is to get rid of all the cards in your hand. Also like UNO, there are reverse cards, skip cards, 0 value cards, etc. If you play certain cards, you have to make particular bathroom-related noises.
It took us a few rounds to get the rules right but once we got it, Drama Guy won our game.
I'd play again. There's enough subtle strategy involved to be able to see beyond the disgusting concept. It's recommended for 5 and up so definitely intended for families with the right sense of humor. There are expansions and variants, too. I'm a sucker for those.